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NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.
Goedert M. Goedert M. Science. 2015 Aug 7;349(6248):1255555. doi: 10.1126/science.1255555. Science. 2015. PMID: 26250687 Review.
The pathological assembly of Abeta, tau, and alpha-synuclein is at the heart of Alzheimer's and Parkinson's diseases. Extracellular deposits of Abeta and intraneuronal tau inclusions define Alzheimer's disease, whereas intracellular inclusions of alpha-synuclein make up th …
The pathological assembly of Abeta, tau, and alpha-synuclein is at the heart of Alzheimer's and Parkinson's diseases. Extracellular d …
Clinical considerations in early-onset cerebral amyloid angiopathy.
Banerjee G, Collinge J, Fox NC, Lashley T, Mead S, Schott JM, Werring DJ, Ryan NS. Banerjee G, et al. Brain. 2023 Oct 3;146(10):3991-4014. doi: 10.1093/brain/awad193. Brain. 2023. PMID: 37280119 Free PMC article. Review.
In this review, we firstly describe the causes of early-onset CAA, including monogenic causes of amyloid-beta CAA (APP missense mutations and copy number variants; mutations of PSEN1 and PSEN2) and non-amyloid-beta CAA (associated with ITM2B, CST3, GSN, PRNP and TTR mutati …
In this review, we firstly describe the causes of early-onset CAA, including monogenic causes of amyloid-beta CAA (APP missense mutations an …
Doppel: the prion's double.
Golańiska E, Flirski M, Liberski PP. Golańiska E, et al. Folia Neuropathol. 2004;42 Suppl A:47-54. Folia Neuropathol. 2004. PMID: 15449459 Review.
Doppel (Dpl) is a PrP-like protein, coded by a gene named PRND, located near the PRNP (prion proten coding gene) locus. Human Dpl is a 179-amino acid protein showing approximately 25% sequence identity with the carboxyproximal two thirds of the human cellular prion protein …
Doppel (Dpl) is a PrP-like protein, coded by a gene named PRND, located near the PRNP (prion proten coding gene) locus. Human Dpl is …
Expression of the prion protein gene (PRNP) and cellular prion protein (PrPc) in cattle and sheep fetuses and maternal tissues during pregnancy.
Thumdee P, Ponsuksili S, Murani E, Nganvongpanit K, Gehrig B, Tesfaye D, Gilles M, Hoelker M, Jennen D, Griese J, Schellander K, Wimmers K. Thumdee P, et al. Gene Expr. 2007;13(4-5):283-97. doi: 10.3727/000000006780666984. Gene Expr. 2007. PMID: 17605301 Free PMC article.
The fetal tissues of both species included brain, cotyledon, heart, intestine, kidney, liver, lung, and muscle. In cattle, prion protein gene (PRNP) transcripts were detected by semiquantitative RT-PCR in reproductive tissues such as ovary, oviduct, endometrium, myo …
The fetal tissues of both species included brain, cotyledon, heart, intestine, kidney, liver, lung, and muscle. In cattle, prion prot …
Phenotypic profiles and functional genomics in Alzheimer's disease and in dementia with a vascular component.
Cacabelos R, Fernández-Novoa L, Corzo L, Amado L, Pichel V, Lombardi V, Kubota Y. Cacabelos R, et al. Neurol Res. 2004 Jul;26(5):459-80. doi: 10.1179/016164104225017677. Neurol Res. 2004. PMID: 15265264 Review.
The phenotypic profile of patients with DVC differs from that of AD patients in the following: anthropometric values (weight, height); cardiovascular function (ECG, heart rate); blood pressure; lipid metabolism (HDL-CHO, TGs); uric acid metabolism; peripheral calcium homeo …
The phenotypic profile of patients with DVC differs from that of AD patients in the following: anthropometric values (weight, height); cardi …
Identification of Target Genes in Hypertension and Left Ventricular Remodeling.
Pang B, Hu C, Wu G, Zhang Y, Lin G. Pang B, et al. Medicine (Baltimore). 2020 Jul 10;99(28):e21195. doi: 10.1097/MD.0000000000021195. Medicine (Baltimore). 2020. PMID: 32664164 Free PMC article.
RESULTS: Twenty-one genes (SEC14L3, EML7, PSMD7, PSMA1, GLRX, CNOT10, NBR1, DUSP12, STRAP, SMIM14, RBM8A, TMEM59, TMEM87A,PSMC1, CASP4, ITGB8, DNAJA1, PINK1, PRNP, SAP30L, and EIF3M) were found overexpression in both hypertension and hypertensive LV remodeling. ...Finally, …
RESULTS: Twenty-one genes (SEC14L3, EML7, PSMD7, PSMA1, GLRX, CNOT10, NBR1, DUSP12, STRAP, SMIM14, RBM8A, TMEM59, TMEM87A,PSMC1, CASP4, ITGB …
Lack of association between PRNP M129V polymorphism and multiple sclerosis, mild cognitive impairment, alcoholism and schizophrenia in a Korean population.
Choi IG, Woo SI, Kim HJ, Kim DJ, Park BL, Cheong HS, Pasaje CF, Park TJ, Bae JS, Chai YG, Shin HD. Choi IG, et al. Dis Markers. 2010;28(5):315-21. doi: 10.3233/DMA-2010-0711. Dis Markers. 2010. PMID: 20592456 Free PMC article.
The genetic variant at codon 129 (M129V) of the prion protein gene (PRNP) is considered to be a major genetic risk factor for prion diseases. ...These findings were discussed in the context of prior inconsistent reports on the role of PRNP*129Val polymorphism in sev …
The genetic variant at codon 129 (M129V) of the prion protein gene (PRNP) is considered to be a major genetic risk factor for prion d …
Up-regulation of mRNA ventricular PRNP prion protein gene expression in air pollution highly exposed young urbanites: endoplasmic reticulum stress, glucose regulated protein 78, and nanosized particles.
Villarreal-Calderon R, Franco-Lira M, González-Maciel A, Reynoso-Robles R, Harritt L, Pérez-Guillé B, Ferreira-Azevedo L, Drecktrah D, Zhu H, Sun Q, Torres-Jardón R, Aragón-Flores M, Calderón-Garcidueñas A, Diaz P, Calderón-Garcidueñas L. Villarreal-Calderon R, et al. Int J Mol Sci. 2013 Nov 28;14(12):23471-91. doi: 10.3390/ijms141223471. Int J Mol Sci. 2013. PMID: 24287918 Free PMC article.
Light microscopy and transmission electron microscopy studies were carried out in human ventricles, and electron microscopy studies were also done in 5 young, highly exposed Mexico City dogs. There was significant left ventricular PRNP and bi-ventricular GRP78 mRNA up-regu …
Light microscopy and transmission electron microscopy studies were carried out in human ventricles, and electron microscopy studies were als …
Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function.
Wood AR, Foliaki ST, Groveman BR, Walters RO, Williams K, Yuan J, Zou WQ, Haigh CL. Wood AR, et al. Sci Rep. 2022 Sep 22;12(1):15788. doi: 10.1038/s41598-022-19631-5. Sci Rep. 2022. PMID: 36138047 Free PMC article.
We differentiated cardiomyocyte cultures from donor human induced pluripotent stem cells and found a direct influence of the PRNP E200K mutation on cellular function. The PRNP E200K cardiomyocytes showed abnormal function evident in the irregularity of the rapid rep …
We differentiated cardiomyocyte cultures from donor human induced pluripotent stem cells and found a direct influence of the PRNP E20 …
Distribution of peripheral PrP(Sc) in sheep with naturally acquired scrapie.
Garza MC, Monzón M, Marín B, Badiola JJ, Monleón E. Garza MC, et al. PLoS One. 2014 May 14;9(5):e97768. doi: 10.1371/journal.pone.0097768. eCollection 2014. PLoS One. 2014. PMID: 24828439 Free PMC article.
Adrenal gland, pancreas, heart, skin, urinary bladder and mammary gland were positive for PrPSc by immunohistochemistry and IDEXX HerdChek scrapie/BSE Antigen EIA Test in at least one animal. ...To our knowledge, this is the first report regarding the presence of PrPSc in …
Adrenal gland, pancreas, heart, skin, urinary bladder and mammary gland were positive for PrPSc by immunohistochemistry and IDEXX Her …
27 results